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Carbohydrate Structure and Function

The structure of Plasmodium falciparum glycosylphosphatidylinositols (GPIs) determined by  Dr. Gowda’s laboratory (R. S. Naik, et al. J. Exp. Med. 192, 1563-1575.).  The parasite GPIs activate macrophages through TLR2-mediated signaling to induce the expression of pro-inflammatory cytokines. Excessive pro-inflammatory cytokines in response to infection leads to severe malaria and the parasite GPIs are suggested as malaria pathogenicity factors.

Images provided by Gowda Lab.

Lab Performing This Type of Research

Gowda Lab