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2014 Annual Biochemistry Retreat

2014 Annual Biochemistry &  Molecular Biology Retreat

RetreatImage2014

Friday, September 19, 2014

 

8:30 AM - 5 PM

University Conference Center

Biochemistry and Molecular Biology Department Retreat 2014

8:30 – 9:00   Breakfast

9:00 – 9:10   Welcoming remarks – Jim Broach

SESSION 1: GENETICS AND GENOMICS 

Moderator: Feng Yue

9:10 – 9:25   Tom Spratt, Associate Professor

Interrogation of the mutagenic potential and mechanism of a thymine adduct of a potent tabacco-specific nitrosamine

9:25 – 9:40   Vasudha Bharatula, Graduate Student (Broach lab)

Regulation of stress induced gene expression:  A dynamic nexus between nucleosome remodeling and Msn2 binding

9:40 – 9:55   Joel Coble (Gerhard lab)

The contribution of LAMB4 and COL1A1 to development of Diverticular Disease

KEYNOTE SPEAKER

9:55 – 10:30   Gerd A. Blobel, University of Pennsylvania

Functions, mechanisms and therapeutic potential of chromatin looping

10:30 – 10:45   Coffee Break

SESSION 2:   EPIGENOMICS AND CHROMATIN DYNAMICS

  Moderator: Laura Carrel

10:45 – 11:00   Feng Yue, Assistant Professor

Dynamic enhancer landscaping during pancreatic differentiation of human Embryonic Stem cells (hESC). 

11:00 – 11:15   Chunhua Song (Dovat Lab)

Restoring Ikaros Tumor Suppression as a Therapy for High-Risk Leukemia

11:15 – 11:30   Sherri Rennoll (Yochum Lab)

A single T-cell factor binding element is required for oncogenic MYC expression

11:30 – 11:45   Sergei Grigoryev, Professor

A glimpse into intrinsic organization of condensed chromatin: irregular zigzag folding and flaking of a nucleosome chain facilitate interactions between distal nucleosomes

KEYNOTE SPEAKER

11:45 – 12:20   Thomas Gingeras, Cold Spring Harbor Laboratory

  Tale of Two Gene Clusters

12:20 – 2:15   LUNCH AND POSTER SESSION

SESSION 3:   CANCER MODELS AND THERAPY

  Moderator: George-Lucian Moldovan

2:15 – 2:30   Katherine Choe (Moldovan lab)

Investigating the mechanism of HUWE1 in mutagenesis and genomic stability

2:30 – 2:45   Raghu Sinha, Assoicate Professor

Methionine Restriction: A Potential Cancer Prevention Strategy in TRAMP Mice

2:45 – 3:00  Mohamed Akl (Mulder Lab)

Critical of km23-1/dynlrb1 in anchoring-mediated assembly of motility  

signaling complexes

3:00 – 3:15   Yuan-wan Sun (El-Bayoumy Lab)

Tissue distribution, excretion and pharmacokinetics of the environmental pollutant and the tobacco smoke constituent dibenzo[a,l]pyrene in mice

3:15 – 3:30   Heather Lehman (Stairs Lab)

p120-catenin down-regulation and EGFR overexpression cause esophageal squamous cell carcinoma invasion

3:30 – 3:45   Coffee break

SESSION 4:   STRUCTRUAL BIOLOGY AND TISSUE STRUCTURE

  Moderator: Greg Yochum

3:45 – 4:00   Xinsheng Wang (Collaboration Tian and Flanagon lab)

Two functional loops play an important role in the regulation of tight junction

4:00 – 4:15   Prem Kumar Sinha (Rösgen Lab)

  Small Molecules (Osmolytes): Role in Macromolecular Stability

4:15 – 4:30   Yifu Ding and Feng Sun (Cheng Lab)

Developing Automated Tools for Phenotyping of 3D Tissue   Architecture from PANCETTO Imaging

KEYNOTE SPEAKER

4:30 – 5:05       Yijun Ruan, Jackson Laboratory 

  3D genome conformation and gene transcription regulation

5:05 – 5:10   Closing remarks – Jim Broach