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Graduate Faculty

Name Research Area(s) PSU Profile
Maria C. Bewley, Ph.D. Using hybrid structural techniques such as x-ray crystallography and SAXS to model dynamic protein complexes. Bewley Profile
James R. Broach, Ph.D.  Cellular responses to environmental and nutritional signals; systems biology of cell growth and behavior. Broach Profile
Laura Carrel, Ph.D. Genetic, epigenetic, and genomic regulation of expression on the mammalian X chromosome. Carrel Profile
Keith C. Cheng, M.D., Ph.D.  The Cheng lab is interested in genetic and molecular mechanisms underlying phenotypes including cancer, skin pigmentation, and human disease, creating high-throughput whole-body phenotyping tools for basic science and medicine, and contributing to web-based infrastructures for science, education, and public service. Cheng Profile
Gary A. Clawson, M.D., Ph.D. HtrA1 as a putative tumor suppressor; Circulating tumor cells in cancer prognosis and detection; Aptamers Clawson Profile
Arunangshu Das, Ph.D.   Chemical Carcinogenesis and Chemoprevention Das Profile
David Degraff, Ph.D. Novel drug targets for bladder and prostate cancer treatments Degraff Profile
Sinisa Dovat, M.D., Ph.D. Pediatric Hematology-Oncology Dovat Profile
Kristin A. Eckert, Ph.D. Mechanisms of microsatellite sequence variation and human genome evolution; DNA replication of common fragile sites; DNA polymerase biochemistry and fidelity Eckert Profile
Karam E. El-Bayoumy, Ph.D. Molecular mechanisms of carcinogenesis and cancer chemoprevention. El-Bayoumy Profile
John M. Flanagan, Ph.D. Structural biology and biophysics of the assembly and regulation of protein complexes. Flanagan Profile
D. Channe Gowda, Ph.D.  Malaria parasite-host interactions involved in malaria pathogenesis and the development of protective immunity. Gowda Profile
Sergei A. Grigoryev, Ph.D. Structure-functional relationship in chromatin; epigenetic changes in cell differentiation and cancer. Grigoryev Profile
Faoud T. Ishmael, M.D., Ph.D. Mechanisms of autoimmune and allergic inflammation; Post-transcriptional gene regulation by microRNAs and RNA binding proteins. Ishmael Profile
Ralph L. Keil, Ph.D. Molecular genetic studies in S. cerevisiae to investigate the cellular activities of volatile anesthetics; Iron bioavailability using S. cerevisiae as a carrier. Keil Profile
Gail L. Matters, Ph.D. Characterizing the role of CCK receptors and ligands in pancreatic cancer. Matters Profile
Barbara A. Miller, M.D. Role of TRP channels in cell proliferation and chemotherapy resistance Miller Profile
George Lucian Moldovan, Ph.D. DNA damage repair and genomic instability in cancer. Moldovan Profile
Kathleen M. Mulder, Ph.D. We have identified the TGFβ receptor-interacting protein km23-1/dynlrb1, which plays an important role in TGFβ signal transduction, as well as in dynein-mediated intracellular transport of signaling cargoes to specialized locales. km23-1 also functions as a critical platform for the assembly of small GTPases, underlying its critical roles in cell signaling, motility, polarity, and in coupling TGFß receptor activation to activation of Ras effector pathways downstream.  We are also investigating mechanisms of TGF-beta signaling in cancer and non-cancer cells, involving cell signaling, cell migration/invasion, actin cytoskeleton, motor proteins, intracellular trafficking, Ras, MAPKs, Smads, and dynein.  Additional studies address how these events are altered in human cancers, as well as how km23-1 can be targeted therapeutically.  The overall focus of the Mulder Lab is the elucidation of km23-1’s functions in cell signaling and motility, and the identification of novel signal transduction-based therapeutics for human colon and pancreatic cancer. Mulder Profile
Christopher Niyibizi, Ph.D. Biology of Stem cells and their application in musculoskeletal tissue repair and regeneration. Niyibizi Profile
Daniel Notterman, M.D.   Tumor biology, gene-environment interactions in child development, and the genetic basis of autism. Notterman Profile
Ira J. Ropson, Ph.D. Protein folding, structure and function in disease. Ropson Profile
Jörg Rösgen, Ph.D.   The role of osmolytes in normal body function, how pathologic deviations may contribute to disease, and how osmolyte use in the body may be manipulated to promote health. Rösgen Profile
Raghu Sinha, Ph.D. Mechanisms of breast and prostate cancer prevention. Sinha Profile
Thomas E. Spratt, Ph.D. DNA repair and mutagenesis, extending from mechanistic enzymology to how these processes lead to inter-individual differences in cancer susceptibility and response to cancer therapeutics. Spratt Profile
Douglas Stairs, Ph.D. Understanding the mechanisms of cancer development in the lung and esophagus including the interactions of tumor suppressor genes and oncogenes involved in these cancers. Stairs Profile
Fang Tian, Ph.D. Biochemistry and biophysics of lipids and membrane proteins; NMR spectroscopy. Tian Profile
Gregory S. Yochum, Ph.D. Wnt/beta-catenin signaling in intestinal homeostasis and disease. Yochum Profile
Feng Yue, Ph.D. My research is focused on understanding the fundamental mechanisms controlling gene expression in mammalian cells. Yue Profile