Penn State University | College of Medicine | Research Departments | George T. Harrell Library | Medical Center |  Clinical & Translational Science Institute


Name Research Area(s) PSU Profile
Donald Gill, PhD Donald Gill, Ph.D. Our research focuses on calcium signaling.  Although calcium is known best for its role in the structure of bones and teeth, calcium plays an even more fundamental physiological role in controlling the essential functions of every cell type in the body. Calcium is pumped out of cells, and then flows back into cells through highly regulated calcium channels.  The calcium signals so generated control such basic functions as contraction, secretion, excitation, and the growth, division and death of cells.  Calcium entry channels are recognized as crucial regulatory targets through which the function of many cell types can be pharmacologically controlled.  Our laboratory studies the function and control of calcium signals generated through the activation of calcium channels. Gill Profile
 Alam Samina Alam, Ph.D. Alam Profile
 Bronson,Sarah_pp Sarah K Bronson, Ph.D. Murine genome manipulation via embryonic stem cells; rodent models of diabetes Bronson Profile
 Chiang,Hui-Ling_pp Hui-Ling Chiang, Ph.D. Molecular mechanisms responsible for the transport of exosomes across the plasma membrane. Exosomes participate in cell-cell communication and have been used for gene therapy and biomarker discovery. We use genetics, cell biology, and molecular biology approaches to study the molecular mechanisms responsible for the secretion and internalization of exosomes using Saccharomyces cerevisiae and Danio rerio as our model systems. Chiang Profile
 Coleman,Catherine_pp Catherine Coleman, Ph.D. Structure and regulation of short-lived proteins; protein turnover in sepsis-induced muscle wasting Coleman Profile
 Dennis,Michael_pp Michael Dennis, Ph.D. Molecular mechanisms that contribute to altered gene expression patterns in disease states, with a particular emphasis on diabetes.  Areas of focus include the impact of post-translational modification (i.e., phosphorylation and O-GlcNAcylation) of eukaryotic translation initiation factors (eIFs) and regulation of the master kinase mammalian target of rapamycin (mTOR.) Dennis Profile
  Ping Nian He,  Ph.D. Cellular and molecular mechanisms that regulate microvessel permeability under physiological and pathological conditions. Special focuses on increased circulating microparticles in diabetes-associated microvascular complications, and the impact of diabetes-induced changes in hemorheological parameters on microvessel function and organ perfusion. We use individually perfused intact microvessels to investigate the signaling pathways and vascular wall structural changes that contribute to the changes of microvascular functions.  Both animal and patient blood samples are used to identify biomarkers for vascular complications. The experimental approaches include flow cytometry, and conventional and confocal fluorescence imaging in individually perfused microvessels and engineered microvessels using microfluidic devices in combination with electron microscopic studies. He Profile
 Hong,Ly_pp Ly Hong-Brown,  Ph.D. Molecular mechanisms and signaling cascades that regulate muscle protein metabolism following exposure to stress modulators Brown Profile
Leonard S Jefferson, Jr., Ph.D. Signaling pathways and molecular mechanisms through which nutrients, hormones and exercise act to mediate translational control of gene expression (i.e. selection of mRNAs for translating into protein). Particular focus is on metabolic diseases such as type 1 and type 2 diabetes and obesity as well as muscle wasting conditions such inactivity, immobilization, and ageing. Jefferson Profile
Shannon Kelleher, Ph.D. Cellular and molecular mechanisms that regulate zinc transport and channel function in highly specialized secretory cells. Areas of focus include hormone and cytokine regulation of zinc transport in mammary epithelial cells and dysregulation in breast cancer, the regulation of zinc transport in Paneth cells, and the role of Nutrigenomics in modifying mammary gland function during lactation and gastrointestinal function during neonatal development. Kelleher Lab Website 
 Kimball,Scot_pp Scot R Kimball, Ph.D. Molecular mechanisms and signaling pathways that regulate alternative splicing of pre-mRNA and mRNA translation in skeletal muscle and liver.  In muscle the focus is on both anabolic (i.e. resistance exercise and nutrients) and catabolic (e.g. disuse atrophy and ageing) conditions; in liver the focus is on metabolic diseases such as obesity and type 2 diabetes. Kimball Profile
 Lang,Charles_pp Charles H Lang, Ph.D. Hormone and nutrient control of muscle protein metabolism during catabolic states, such as sepsis and alcoholism Lang Profile
 Lynch,Christopher_pp Christopher J Lynch, Ph.D. Cellular and integrative physiology of metabolic diseases including diabetes, obesity and MSUD; Metabolomics; Metabolic phenotyping Lynch Lab
Website Page
 Peterson,Blaise_pp Blaise Peterson, Ph.D.  Molecular defects that lead to cardiac arrhythmias and heart disease Peterson Profile
 Shantz,Lisa_pp Lisa Shantz, Ph.D.  Signal transduction pathways in non-melanoma skin carcinogenesis Shantz Profile
Shi,Yuguang_pp Yuguang Shi, Ph.D. Translation research on age-related metabolic diseases, including diabetes, obesity, and cardiovascular diseases. Molecular mechanisms underlying islet beta cell dysfunction in type 2 diabetes. Shi Profile
Stocker Web Photo Sean Stocker, Ph.D. Neural contributions to cardiovascular disease including obesity and salt-sensitive hypertension Stocker Profile
Yengo,Christopher_pp Christopher Yengo, Ph.D. Biophysical properties of molecular motor proteins, regulation of the actin cytoskeleton, enzyme kinetics, and molecular mechanisms of myosin based motility. We investigate mechanisms of contractile dysfunction in heart failure and inherited cardiomyopathies. We also study the impairments in actomyosin-based transport and regulation of the actin cytoskeleton in sensory cells, which are associated with deafness and retinal degeneration. Yengo Profile
Zhou,Yandong_pp Yandong Zhou, Ph.D. Zhou Profile

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