Penn State Hershey Research Breakthroughs

Timeline

1974: Long-life rechargeable heart pacemaker developed.Scientist conducting research with microscope

1976: First surgically implantable, seam-free, pulsatile blood pump to receive widespread clinical use developed.

1982: A new therapy for the treatment of congenital coarctation of the aorta in infants created. Reduced mortality from 60 percent to 3 percent, reduced recurrence of the disease from 30 to 0 percent, and has been universally accepted.

1985: First recipient of the Penn State Heart was sustained for 10 days at the Milton S. Hershey Medical Center.

1985: John W. Kreider discovered the only system known for the propagation of cancer-associated papillomaviruses in a controlled, experimental environment.

Other Discoveries

Penn State research on ferroelectric and related materials has led to modern technologies, including high-speed computers, underwater acoustic detection and signal services, and acoustic-based medical scanners.

In cardiac research, investigators learned how the working heart uses sugar; the link between protein metabolism and damage to the heart muscle during a heart attack; and how an injured heart grows.

Hershey Medical Center pioneered studies establishing IGFs – particularly insulin-like growth factors – as necessary and important for the growth and maturation of ovarian follicles.

The “stopped flow” and “chemical quench flow” apparatuses helped to understand the cycle that coordinates molecular ciliary wave motion.

Human RPE cells 3- Tombran-Tink labInnovative ways of using sophisticated new techniques such as nuclear magnetic resonance have led to research regulatory methods of ATP synthesis.

Penn State was the first to use molecular genetics tools and molecular biology to better understand the regulation of surfactant protein genes, lung development, and the genetic basis of neonatal respiratory distress syndrome.

Cellular compartmentalization, video imaging, and the use of microspectrofluorometry were used  to measure intracellular free calcium, a key to understanding cardiac metabolism.

For the first time, researchers successfully grafted tissue from the uterus into nude mice and used them as an in vivo model for investigating the influence of hormones on cancer growth and on other cancer constituents, such as receptors and enzymes.Global-Health

Researchers developed a new way of analyzing mitochondrial DNA differences among human populations that reveals ancient episodes of population growth before the last ice age.

Researchers were able to show the first direct acceleration of growth of primary human endometrial cancer by estradiol.

Research on prolactin paved the way for further research in hormone release mechanisms.

The bidirectional effects of the pituitary gland system on the brain were recognized as fundamentally important for understanding the mechanisms of neuroendocrine regulation.